Welcome to A4liveCell Blog #9! The Free Radical Theory of Ageing Ageing is an intrinsic biological process characterized by the gradual decline in cellular and molecular function over time. It involves disruptions in normal cellular mechanisms, the buildup of damaged molecules and toxins, changes in gene expression, and weakened immune and stress responses. Although extensively […]
Welcome to A4liveCell Blog #8! Cell Senescence & the Links to Homeostasis of Calcium, pH, and Oxidative Stress As our understanding of cellular biology evolves, one of the most compelling areas of research is the phenomenon of cellular senescence—a state of permanent cell cycle arrest that occurs when cells experience stress or damage. Factors such […]
IntroductionReactive oxygen species (ROS) are chemically reactive molecules containing oxygen that play a dual role in cellular biology. At controlled levels, ROS participate in signaling pathways crucial for normal physiological functions such as cell growth and defense mechanisms. However, excessive ROS production leads to oxidative stress, which has been linked to cellular damage, inflammation, aging, […]
Welcome to A4liveCell Blog #7! Hydroxyl Radical, the dark messengerconnecting Ferroptosis and Doxorubicin-Induced Cardiotoxicity (DIC) The connection between ferroptosis and doxorubicin-induced cardiotoxicity (DIC) has emerged as a critical area of research, offering new insights into the underlying mechanisms of this cardiac toxin and how to address its adverse effects in cancer patients. Doxorubicin (DOX) is […]
Welcome to A4liveCell Blog #6! SPAchip® as an image-based real-time readout of metabolic activity in genetic screening Understanding how the genetic information give rise to the phenotype, and how genomic perturbation affects a given phenotype are some of the main objectives of genetic screening. Recently, microscopy or FACS-based screening have emerged as new option to […]
Welcome to A4liveCell Blog #5! 3D Cell Culture Tips & Tricks: Zonal analysis of spheroid physiology with SPAchip® in real-time In drug discovery, 3D cellular spheroids have become a powerful model for high-content screening (HCS). Unlike traditional 2D cultures, spheroids more accurately mimic the in vivo environment, providing more reliable and physiologically relevant data. This […]
Welcome to A4liveCell Blog #4! Unlocking the Secrets of Ageing with SPAchip® technology As scientists delve deeper into the intricacies of ageing, they are uncovering a range of molecular hallmarks that hold the key to understanding this complex process. From telomere shortening to mitochondrial dysfunction, these mechanisms shape our journey through life, influencing our health […]
Welcome to A4liveCell Blog #3! SPAchip® technology enables the study of calcium signaling in receptor pharmacology. Calcium ions (Ca2+) are one of the most important signal transducers in cells, hence intracellular levels must be tightly regulated since prolonged high levels can lead to cell death. Since extracellular calcium concentration is usually 20,000-fold higher than intracellular […]
Work Site: Pozuelo de Alarcon. Madrid (SPA) About the Role: We are seeking a Data Image Analyst with expertise in High Content Screening (HCS) Techniques and Live Cell Imaging Software. This is an exceptional opportunity for a skilled professional to join our dynamic team and play a crucial role in advancing our innovative projects. Key […]
In the dynamic landscape of drug discovery, precision is paramount. High content screening (HCS) assays serve as indispensable tools, providing invaluable insights into cellular responses to various compounds. Yet, amidst the complexity of experimental design, two crucial factors often overshadowed are drug redosing and confluence levels, both wielding significant influence over assay outcomes. Drug Redosing: […]
Arrays for Cell Nanodevices S.L. ha participado en el Programa de Iniciación a la Exportación ICEX-Next, y ha contado con el apoyo de ICEX, así como con la cofinanciación de Fondos europeos FEDER, habiendo contribuido según la medida de los mismos, al crecimiento económico de esta empresa, su región y de España en su conjunto.
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